I play the electric, acoustic and resonator guitar; all have a completely different sound and all probably would benefit from an Amplifier (amp/amps) and speaker designed just for each one and sometimes you can get them. There are 2 types of amps used and 2 types of speaker enclosures. Solid State and tube are the amps and open speaker cabinets (cabs) and mostly sealed cabs.
The open cabs are usually combination (or combo) amps that house the amplifier AND the driver and the other has a separate enclosures for the amp and the drivers. I say they are mostly closed because the cabs are connected to the amp with a 2 conductor 1/4" jack; sometimes shielded cable is used; so there is at least one if not two 1/4" holes in the back of the cab. Sometimes the driver is installed from the front of the housing and sometimes from the back. Many times you'll see a Celestion used in the famous 4 X 12" 1961A and B cabs Marshall makes. Marshall uses the same model speakers in combo (open cab) amps and the other mostly sealed cabs. The same speaker sounds way different in each application. I'm a big fan of the mostly closed cabs, I can't see how one or two 1/4" holes in the back of a cab can be called a vent but by definition they are vents, the combo cabs remind me of my Father's Sylvania Mono Hi Fi from the late 50's with radio and turn table, it had one 12" and one 4" driver with a simple crossover. It had a Masonite cover on the back that was vented for the tube heat generated inside, it had horizontal openings for air to get in and out and I'm sure some of the sound but I'm also sure that wasn't on the minds of the engineers at the time.
I know guitar amp drivers aren't made anything like a fine audio driver, the guitar driver has a lot less to do. I have never heard the amount of differences in stereo amp/driver quality that I have with guitar equipment. I belong to the tube amp side of the discussion, they provide a warmer sound, have a more natural distortion although solid state amps have a lot to offer and are getting better every year. Many solid state amps try to sound like tube amps, no tube amp manufacturer (MFR) will ever try to emulate a solid state sound.
So what would make a great guitar driver? What would make a great enclosure? Those are questions that will have subjective answers of course. But as we all know facts are inconvenient things. Certainly we can apply Hi Fi speaker technology to this question.
In guitar amps high wattage doesn't mean a lot louder, the decibel difference in say a 20 or 30 watt amp and a 100 watt amp is about 7 decibels. If you drive the 20 watt amp (turn it up) it's going to distort a lot easier/earlier than the 100 watt amp, the big difference is "head room" or the ability to go loud without distortion.